Custom Peptides
Cayman Chemical S-Docosahexaenyl-2-Hyd 10mg
A homolog of DHEA, characterized by the addition of an (S)-β-methyl group at the terminal ethanolamine carbon
Cayman Chemical SemaglutIde MaIn ChaIn937 10mg
A peptide starting material in the synthesis of semaglutide
Cayman Chemical 7ahydroxy DehydroepIndROS 10mg
An active metabolite of dehydroepiandrosterone; formed from dehydroepiandrosterone via 7-hydroxylation by CYPs; increases antigen-induced production of anti-tetanus toxoid and anti-pertussis antigen IgGs in co-cultures of human tonsil-derived B and T cells at 1 µM; increases serum concentrations of anti-lysozyme IgG in mice at 6.25 mg/kg
Cayman Chemical 28-AcetylbetulIn 10mg
A lupane triterpenoid with anti-inflammatory and anticancer activities; inhibits LPS-induced NO and PGE2 production by 55.9 and 69.5%, respectively, in RAW 264.7 cells (IC50s = 4.7 and 1.7 µM, respectively); induces cytotoxicity in a variety of cancer cells, including A549, HT-29, and MCF-7 cells (IC50s = 14.37, 10.96, and 11.38 µM, respectively)
Cayman Chemical CalycosIn 7-OD-GlucosIde 10mg
An isoflavone glycoside; scavenges 34.5% of generated DPPH radicals compared to a vehicle control in a cell-free assay at 100 μg/ml; inhibits LPS-induced cytotoxicity, ROS production, and cytoskeletal defects in HUVECs at 10 μg/ml; reduces brain infarct volume in a rat model of ischemia-reperfusion injury induced by MCAO at 26.8 mg/kg
Cayman Chemical LavendustIn B 10mg
An inhibitor of Glut1 (Ki = 15 µM); an inhibitor of the interaction between HIV-1 integrase and LEDGF/p75 (IC50 = 94.07 µM); a weak inhibitor of tyrosine kinases (IC50 = 0.49 UG/ml); and has been used as a negative control for lavendustin A
Cayman Chemical 17phenyl trInor Prostglnd 10mg
Derived from 17-phenyl trinor PGE2, a synthetic analog of PGE2 that acts as an agonist of EP1 and EP3 in mice (Ki = 14 and 3.7 nM, respectively) and EP1, EP3, and EP4 in rats (Ki = 25, 4.3, and 54 nM, respectively); the ethyl amide group increases lipid solubility, lowering the effective concentration
Cayman Chemical Lusutrombopag 10mg
A thrombopoietin receptor agonist; induces proliferation of Ba/F3 cells expressing human MPL (EC50 = 84 nM) but not of those expressing mouse Mpl; increases the number of circulating platelets in a transgenic mouse model expressing human MPL at 0.3-10 mg/kg per day and increases the number of megakaryocytes in the bone marrow at 10 mg/kg per day
Cayman Chemical 2-O-GaloylhyperIn 10mg
A natural flavonoid; scavenges DPPH and ABTS radicals (IC50s = 3 and 3.5 μM, respectively); inhibits human OATP1B1 (IC50 = 19 μM in HEK293 cells); decreases LPS-induced IL-6 and TNF-α cytokine production from mouse RAW 264.7 macrophages at 15 μM; decreases LPS-induced mortality and liver damage in a mouse model of septic shock at 50 mg/kg
Cayman Chemical NodInItIb-1 10mg
Selectively inhibits NOD1-dependent activation of NF-κB and MAPK signaling (IC50 = 0.6 μM) and also inhibits NOD1-induced IL-8 production in MCF-7 cells without affecting viability
Cayman Chemical ChIcorIc AcId 10mg
A dicaffeoyl ester with diverse biological activities; reduces the viability of Caco-2 and HCT116 colorectal cancer cells from 50-200 μg/ml; inhibits the 3'-processing and DNA integration activities of HIV integrase (IC50s = 1.1 and 0.8 μM, respectively); inhibits HIV entry into H9 cells at 5 μM; oral administration reduces hepatic lipid accumulation, lipid peroxidation, and fibrosis, inhibits production of pro-inflammatory cytokines and activation of NF-kB, and activates the AMPK signaling pathway in a mouse model of NASH induced by a methionine and choline-deficient diet at 10 and 30 mg/kg; reduces blood glucose levels by 54% in mice with streptozotocin-induced diabetes at 2 mg/kg
Cayman Chemical Aunt fumatuus Nautn 10mg
A flavanone; reduces airway sensitivity, eosinophil counts and IL-4 levels in BALF, and serum IgE levels in a mouse model of ovalbumin-induced airway inflammation at 10 mg/kg; decreases immobility in the forced swim test and latency to feeding in the novelty-suppressed feeding test, indicating antidepressant-like activity in mice
