Custom Peptides
Cayman Chemical Ctrus maxa peel Mernzn 10mg
A coumarin with diverse biological activities; cytotoxic to NSCLC-N6 and KB cancer cells (IC50s = 14.6 and 12.3 UG/ml, respectively); increases the latency to paw withdrawal in the hot plate test and reduces xylene-induced EAr edema in mice at 10 mg/kg; decreases carrageenan-induced paw edema in rats at 10 mg/kg
Cayman Chemical BIfeprunoxmesylate 10mg
An atypical antipsychotic; dopamine D2 receptor partial agonist and an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (Kis = 2.2 and 9.3 nM, respectively); inhibits apomorphine-induced climbing behavior in mice (ED50 = 0.1 mg/kg) and the conditioned avoidance response in rats (ED50 = 0.8 mg/kg); decreases basal prepulse inhibition of the acoustic startle response in rats by 42% at 10 mg/kg
Cayman Chemical Xnthotoxol 10mg
A coumarin with diverse biological activities; inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively); increases histamine release from mast cells; decreases DNP-HSA-induced secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells; nematocidal against M. incognita (IC50 = 68 mg/L); inhibits predatory mouse and rat killing behavior in dogs and cats at 3-100 and 5-20 mg/kg, respectively; reduces amphetamine-induced hypermobility in mice and hamsters; reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and NO, and intercellular levels of ICAM-1 and E-selectin in a rat model of focal cerebral ischemia at 5 and 10 mg/kg
Cayman Chemical ACtyl HexapeptID38trIflu 10mg
A hexapeptide; decreases IL-8 secretion in human keratinocytes when used alone or in combination with acetyl pentapeptide-46
Cayman Chemical 4-O-Methylresveratrol 10mg
A stilbene with diverse biological activities; inhibits growth of A549, SKOV3, SK-MEL-2, XF498, and HCT15 cancer cells (IC50s = 3.8, 5.7, 3.2, 5.6, and 6.7 UG/ml, respectively); inhibits arachidonic acid- or collagen-induced rabbit platelet aggregation from 0.05-0.2 mM; scavenges free radicals in a TEAC assay; suppresses RANKL-induced osteoclastic differentiation of murine BMDMs; reduces LPS-induced bone loss in mice at 50 mg/kg
Cayman Chemical BMP2dRIved PeptIDtrIfluo 10mg
A synthetic peptide; increases ALP activity in C3H/10T1/2 murine mesenchymal cells at 100 and 200 UG/well; increases mRNA expression of the gene encoding osteocalcin in C3H/10T1/2 cells at 100 UG/well; induces osteoblast-like cell differentiation and ectopic calcification when conjugated to an alginate gel in rats via a submuscular implant
Cayman Chemical Osntnthydrate 10mg
An NK3 receptor antagonist (Ki = 0.21 nM in CHO cells expressing the human receptor); selective for NK3 over NK1 and NK2 receptors (Kis = >100 and 0.02 µM, respectively); inhibits neurokinin B-induced contractions and acetylcholine release in isolated guinea pig ileal strips; inhibits ovalbumin-induced increases in BALF neutrophil, eosinophil, and lymphocyte infiltration in an ovalbumin-sensitized mouse model of allergic asthma; has anxiolytic-like and antidepressant-like activities in gerbils at 5 and 10 mg/kg
Cayman Chemical ButabIndIdeoxalate 10mg
A potent inhibitor of CCK-inactivating peptidase/TPP-2 (Ki = 7 nM); selective for CCK-inactivating peptidase/TPP-2 over a panel of serine proteases (Kis = >1 μM) as well as CCK receptors (Kis = >0.1 mM); increases levels of CCK octapeptide in depolarized rat cerebral cortex slices; inhibits CCK-inactivating peptidase/TPP-2 in mouse liver and brain (ID50s = 1.1 and 6.8 mg/kg, respectively); enhances CCK octapeptide-induced delay in gastric emptying and reduces food intake in mice
Cayman Chemical PeonIdInchlorIde 10mg
An O-methylated anthocyanidin that exhibits chemopreventive as well as anti-inflammatory activities on cancer cells in vitro, blocking COX-2 expression and transformation in JB6 P+ mouse epidermal cells
Cayman Chemical DesglymIdodrIn 10mg
An active metabolite of midodrine; an agonist of α1-ARs; binds to α1-ARs (Kis = 9.77, 9.55, and 8.51 µM for α1A, α1B, and α1D-ARs, respectively); increases IUP and MAP in anesthetized dogs by 5 and 20 mm Hg, respectively, in anesthetized dogs at 205 and 250 nmol/kg, respectively
Cayman Chemical SynthetIc TectrIdIn 10mg
A flavonoid glycoside and phytoestrogen with diverse biological activities; scavenges hydroxyl radicals in a cell-free assay (IC50 = 178 UG/ml); inhibits the formation of TBARS in egg yolk (IC50 = 86 UG/ml); activates thyroid hormone receptor- or estrogen receptor-mediated transcription in GH3 and MCF-7 cells, respectively, in reporter assays at 200 µM; inhibits thapsigargin-induced production of PGE2 in isolated rat peritoneal macrophages at 10 and 30 µM; inhibits trabecular bone loss in a mouse model of ovariectomy-induced osteoporosis at 60 mg/kg
Cayman Chemical nmonaprde 10mg
An antipsychotic that binds D2-like receptors preferentially over D1-like receptors (Kis = 0.06, 0.3, and 0.15 nM for D2, D3, and D4, respectively); also binds σ1 and σ2 receptors (Kis = 8.4 and 9.6 nM, respectively) and activates the 5-HT1A receptor (IC50 = 34 nM)
Cayman Chemical L-Alanosine 10mg
An inhibitor of adenylosuccinate synthase (mean IC50 = 4.8 μM and 10 μM in T-ALL and CAK-1 cells, respectively); antineoplastic activity in MTAP deficient cells; disrupts de novo purine biosynthesis and inhibits cellular metabolism
Cayman Chemical Gelsemum elegns Koumn 10mg
An alkaloid with diverse biological activities; inhibits the proliferation of MCF-7 cells (IC50 = 124 UG/ml) as well as induces apoptosis and cell cycle arrest at the G2/M phase in the same cells; reduces LPS-induced increases in iNOS, IL-1β, IL-6, and TNF-α levels in RAW 264.7 macrophages at 200 and 400 UG/ml; inhibits acetic acid-induced writhing and formalin-induced paw licking and biting in mice at 2 and 10 mg/kg; increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity, at 0.4-10 mg/kg
Cayman Chemical 3-EpIdeoxycholIc AcId 10mg
A secondary bile acid produced by gut microbiota; increases the growth of Caco-2 cells at 10 and 20 µM; increases Foxp3+CD4+ Treg levels in a co-culture of naïve T cells and dendritic cells